Bupropion, sold under the brand names Wellbutrin and Zyban among others, is a medication primarily used to treat major depressive disorder and to support stopping smoking. It is an effective antidepressant on its own, but is also used as an add-on medication in cases of incomplete response to first-line SSRI antidepressants. Note: This document contains side effect information about bupropion. Some of the dosage forms listed on this page may not apply to the brand name Wellbutrin. I have just been perscribed wellbutrin. Anyway, I am a curious little monkey and likes to experiment with drugs. Are there definate NO-NO's with wellbutrin? Causes of psychosis The exact causes of psychosis are not well understood but might involve: Genetics - research shows that schizophrenia and bipolar disorder may share a common genetic cause. While some patients report that Wellbutrin causes Psychosis, others say it doesn't. I was put on 150mgs of Wellbutrin XL roughly a month ago. In addition to Wellbutrin XL, I was also taking.5mgs of ativan 2x daily prn, 150mgs Straterra, and 100mgs Lamictal before bedtime. Summary. Acute psychosis is found among people who take Wellbutrin, especially for people who are male, 40-49 old , have been taking the drug for 1 month, also take medication Seroquel, and have Insomnia. Q: Wellbutrin; Movement Disorders & Psychosis. I am wondering if wellbutrin could be the source of my movement disorder and my psychotic episode. While some patients report that Wellbutrin causes Psychosis, others say it doesn't.